How Lipotoxicity Relate to Diabetes?

Tuesday, October 1, 2019
Relation of beta cells, insulin and lipotoxicity (credit to Yoon et al, 2018).

Previous post was talking about two metabolic factors that are hyperglycemia (higher blood sugar level) and glucose toxicity (glucotoxicity).

In the article with title: Effect of Metabolic on Beta Cells in the Pancreas, we discussed the hyperglycemia. Then we discuss another metabolic factor, lipotoxicity in this post.

Lipotoxicity is medical term relate to increasing of fat (free fatty acids) in the blood. In present of higher glucose level, Lipotoxicity then have the following effect on:
- resistance to insulin for several organs such as muscle and liver.
- increasing glucose generating
- reduction of insulin production in pancreas.
- promoting unhealthy heart and kidney

Unluckily, these negative effects are increasing for type 2 diabetic patients through less beta cell mass and reduce insulin production in pancreas. 



Illustration of beta cell damage (credit to ScienceDirect)


At cellular level, Lipotoxicity may induce:

- stress on endoplasmic reticulum
- oxidative stress
- impair beta cell production, hence impact on beta cell mass
- inflammation
- authopagy

Luckily, negative effect of Lipotoxicity on beta cell could be protected by several factors such as lactogens, incretins and estrogens.

These hormones not only able to reduce toxicity effect of lipid, but also to stimulate beta cell function and proliferation.

Finally, in this case, we may conclude that not only sugar, lipid may also contribute to impair beta cell to produce insulin.

Reference

Yoon, S, Oh et al. 2019. Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes. Endocrinol., 16 July 2018.

32 comments:

  1. Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Relation of beta cells, insulin and lipotoxicity (credit to Yoon et al, 2018).

      Delete
  2. Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Previous post was talking about two metabolic factors that are hyperglycemia (higher blood sugar level) and glucose toxicity (glucotoxicity).

      Delete
  3. Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      In the article with title: Effect of Metabolic on Beta Cells in the Pancreas, we discussed the hyperglycemia. Then we discuss another metabolic factor, lipotoxicity in this post.

      Delete
  4. Very interesting, we should be all more aware if that!☺

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Lipotoxicity is medical term relate to increasing of fat (free fatty acids) in the blood. In present of higher glucose level, Lipotoxicity then have the following effect on:
      - resistance to insulin for several organs such as muscle and liver.
      - increasing glucose generating
      - reduction of insulin production in pancreas.
      - promoting unhealthy heart and kidney

      Delete
  5. I was glad to learn that Lipotoxicity on beta cell could be protected.
    Best wishes to you from me.

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Unluckily, these negative effects are increasing for type 2 diabetic patients through less beta cell mass and reduce insulin production in pancreas.

      Delete
  6. Great post - thanks for bringing it to our attention!

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Illustration of beta cell damage (credit to ScienceDirect)

      Delete
  7. thanks for these scientific information!!
    xoxo

    marisasclosetblog.com

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      At cellular level, Lipotoxicity may induce:
      - stress on endoplasmic reticulum
      - oxidative stress
      - impair beta cell production, hence impact on beta cell mass
      - inflammation
      - authopagy

      Delete
  8. Hello and thank you for sharing this information. We should all be aware. Enjoy your day. PS, thank for visiting my blog.

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Luckily, negative effect of Lipotoxicity on beta cell could be protected by several factors such as lactogens, incretins and estrogens.

      Delete
  9. Great information! Thanks for sharing with us!

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      These hormones not only able to reduce toxicity effect of lipid, but also to stimulate beta cell function and proliferation.

      Delete
  10. very interesting information - thank you for sharing ☺
    best regards
    Lili

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Finally, in this case, we may conclude that not only sugar, lipid may also contribute to impair beta cell to produce insulin.

      Delete
  11. Very insightful information, thanks for sharing!

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Relation of beta cells, insulin and lipotoxicity (credit to Yoon et al, 2018)

      Delete
  12. Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Previous post was talking about two metabolic factors that are hyperglycemia (higher blood sugar level) and glucose toxicity (glucotoxicity).

      Delete
  13. Thanks for sharing this inspiring post!

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      In the article with title: Effect of Metabolic on Beta Cells in the Pancreas, we discussed the hyperglycemia. Then we discuss another metabolic factor, lipotoxicity in this post.

      Delete
  14. Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Lipotoxicity is medical term relate to increasing of fat (free fatty acids) in the blood. In present of higher glucose level, Lipotoxicity then have the following effect on:
      - resistance to insulin for several organs such as muscle and liver.
      - increasing glucose generating
      - reduction of insulin production in pancreas.
      - promoting unhealthy heart and kidney

      Delete
  15. Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Unluckily, these negative effects are increasing for type 2 diabetic patients through less beta cell mass and reduce insulin production in pancreas.

      Delete
  16. Feel so bad for all that have to go through this

    ReplyDelete
    Replies
    1. Thank you to visit:
      How Lipotoxicity Relate to Diabetes?
      -
      Illustration of beta cell damage (credit to ScienceDirect)

      Delete